Slon: Это я гляну, спасибо.
да, посмотри там же на стр 1254 и найди 3 отличия с нынешней историей
SARS-CoV
The incubation period for SARS-CoV has been estimated to
average 4–6 days, with a range of 1–14 days (121, 122).
SARS begins with acute onset of fever, myalgia, malaise, and
chills and then progresses to cough. Upper respiratory
symptoms of rhinorrhea and sore throat are uncommon.
Dyspnea and tachypnea develop later in the illness; at this
stage, individuals often have scattered ground-glass peripheral
lung infiltrates. Over the course of the next several days,
they either improve gradually or worsen with increasing
oxygen requirements; severe cases progress to acute respiratory
distress syndrome (ARDS). Awatery diarrhea occurs in
some patients, usually associated with clinical deterioration,
mainly in the second week of illness. Other extrapulmonary
manifestations include hepatic dysfunction and CNS manifestations.
Overall mortality is between 9% and 12%,
mortality progressively increasing with age (reviewed in 8,
204, 205).
Chest radiographic abnormalities were present in 60–
100% of patients, depending on duration of illness, and
typically encompass ground-glass opacities or focal consolidation
over the periphery and subpleural regions of the lower
zones of the lung. Bilateral involvement and shifting opacities
are common. High-resolution computed tomography
(CT) scanning reveals abnormalities, even in those with
initially normal chest radiography.
Laboratory abnormalities include leukopenia (particularly
lymphopenia in severe cases) and elevated transaminase
levels. In addition to age, the presence of comorbidities,
more extensive lung involvement, high neutrophil counts,
low CD4 and CD8 counts, and increased lactic dehydrogenase
levels are predictors of a poor prognosis. High viral
loads in nasopharynx and serum early in the illness and
between days 10 and 15 of illness are independent predictors
of a poor outcome.
Atypical (sometimes afebrile) presentations can occur
in the elderly or immunocompromised patients, leading to
delayed recognition, sometimes resulting in nosocomial
transmission.
Three months after hospital discharge, patients convalescing
from SARS have detectable defects in pulmonary
function, but the impairment is mild in almost all cases.
Many patients have reduced exercise capacity, not accounted
for by impairment of pulmonary function (206).